3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
Name
705941957-MIT.pdf
Description
Full printable version
Size
5.01 MB
Format
Adobe PDF
Checksum (MD5)
1c06b186a08bcc7af0edea1975c2d49b
Author(s)
Jeon, Jessie Sungyun
Advisor(s)
Joseph Charest and Roger Kamm.
Alternative Title
Three-dimensional cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
Date Issued
2010
Publisher
Massachusetts Institute of Technology
Abstract
A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of hydrophobicity, production by the more commercially-viable hot embossing technique, and amenability to surface treatments. Here the fabrication process is described and the new systems are characterized. Surface wettability, bond strength between the system body and a covering plastic film, and cell viability data are presented and compared to systems fabricated in PDMS.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 48-51).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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