Learning From Animal Models of Obsessive-Compulsive Disorder
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nihms696272.pdf
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828.81 KB
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Adobe PDF
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Author(s)
Monteiro, Patricia
Feng, Guoping
Date Issued
May 2015
Journal
Biological Psychiatry
Publisher
Elsevier
Citation
Monteiro, Patricia, and Feng, Guoping. “Learning From Animal Models of Obsessive-Compulsive Disorder.” Biological Psychiatry 79, 1 (January 2016): 7–16 © 2016 Society of Biological Psychiatry
Version
Author's final manuscript
Abstract
Obsessive-compulsive disorder (OCD) affects 2%-3% of the population worldwide and can cause significant distress and disability. Substantial challenges remain in the field of OCD research and therapeutics. Approved interventions alleviate symptoms only partially, with 30%-40% of patients being resistant to treatment. Although the etiology of OCD is still unknown, research evidence points toward the involvement of cortico-striato-thalamocortical circuitry. This review focuses on the most recent behavioral, genetics, and neurophysiologic findings from animal models of OCD. Based on evidence from these models and parallels with human studies, we discuss the circuit hyperactivity hypothesis for OCD, a potential circuitry dysfunction of action termination, and the involvement of candidate genes. Adding a more biologically valid framework to OCD will help researchers define and test new hypotheses and facilitate the development of targeted therapies based on disease-specific mechanisms.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.BIOPSYCH.2015.04.020
