Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders
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Brennand-2015-Creating Patient-Spe.pdf
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2.33 MB
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Author(s)
Brennand, Kristen J.
Marchetto, M. Carol
Benvenisty, Nissim
Brustle, Oliver
Ebert, Allison
Izpisua Belmonte, Juan Carlos
Kaykas, Ajamete
Lancaster, Madeline A.
Livesey, Frederick J.
McConnell, Michael J.
Date Issued
November 2015
Journal
Stem Cell Reports
Publisher
Elsevier
Citation
Brennand, Kristen J., M. Carol Marchetto, Nissim Benvenisty, Oliver Brustle, Allison Ebert, Juan Carlos Izpisua Belmonte, Ajamete Kaykas, et al. “Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.” Stem Cell Reports 5, no. 6 (December 2015): 933–945.
Version
Final published version
Abstract
As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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DOI of Published Version
https://doi.org/10.1016/j.stemcr.2015.10.011
