RNF43 is frequently mutated in colorectal and endometrial cancers
Name
nihms648689.pdf
Size
595.09 KB
Format
Adobe PDF
Checksum (MD5)
2c8887ae854729085045f1d519142a63
Author(s)
Giannakis, Marios
Hodis, Eran
Jasmine Mu, Xinmeng
Yamauchi, Mai
Rosenbluh, Joseph
Cibulskis, Kristian
Saksena, Gordon
Lawrence, Michael S
Qian, Zhi Rong
Nishihara, Reiko
Date Issued
October 2014
Journal
Nature Genetics
Publisher
Nature Publishing Group
Citation
Giannakis, Marios et al. “RNF43 Is Frequently Mutated in Colorectal and Endometrial Cancers.” Nature Genetics 46, 12 (October 2014): 1264–1266 © 2014 Nature America, Inc
Version
Author's final manuscript
Abstract
We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/NG.3127
