A simple and fast spectroscopy-based technique for Covid-19 diagnosis
Name
s41598-021-95568-5.pdf
Description
Published version
Size
3.98 MB
Format
Adobe PDF
Checksum (MD5)
414b29bc2a50b1ef64fd909f077cd126
Author(s)
Kitane, Driss Lahlou
Loukman, Salma
Marchoudi, Nabila
Fernandez-Galiana, Alvaro
El Ansari, Fatima Zahra
Jouali, Farah
Badir, Jamal
Gala, Jean-Luc
Bertsimas, Dimitris
Azami, Nawfal
Date Issued
2021
Journal
Scientific Reports
Publisher
Springer Science and Business Media LLC
Citation
Kitane, Driss Lahlou, Loukman, Salma, Marchoudi, Nabila, Fernandez-Galiana, Alvaro, El Ansari, Fatima Zahra et al. 2021. "A simple and fast spectroscopy-based technique for Covid-19 diagnosis." Scientific Reports, 11 (1).
Version
Final published version
Abstract
AbstractThe coronavirus pandemic, which appeared in Wuhan, China, in December 2019, rapidly spread all over the world in only a few weeks. Faster testing techniques requiring less resources are key in managing the pandemic, either to enable larger scale testing or even just provide developing countries with limited resources, particularly in Africa, means to perform tests to manage the crisis. Here, we report an unprecedented, rapid, reagent-free and easy-to-use screening spectroscopic method for the detection of SARS-CoV-2 on RNA extracts. This method, validated on clinical samples collected from 280 patients with quantitative predictive scores on both positive and negative samples, is based on a multivariate analysis of FTIR spectra of RNA extracts. This technique, in agreement with RT-PCR, achieves 97.8% accuracy, 97% sensitivity and 98.3% specificity while reducing the testing time post RNA extraction from hours to minutes. Furthermore, this technique can be used in several laboratories with limited resources.
MIT Department
Massachusetts Institute of Technology. Operations Research Center
LIGO (Observatory : Massachusetts Institute of Technology)
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/S41598-021-95568-5
