High precision particle mass sensing using microchannel resonators in the second vibration mode
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Manalis_High precision.pdf
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Author(s)
Lee, Jungchul
Bryan, Andrea Kristine
Manalis, Scott R.
Date Issued
February 2011
Journal
Review of Scientific Instruments
Publisher
American Institute of Physics (AIP)
Citation
Lee, Jungchul, Andrea K. Bryan, and Scott R. Manalis. “High Precision Particle Mass Sensing Using Microchannel Resonators in the Second Vibration Mode.” Review of Scientific Instruments 82.2 (2011): 023704. © 2011 American Institute of Physics
Version
Final published version
Abstract
An intrinsic uncertainty in particle mass sensing with the suspended microchannel resonator results from variation in a particle's position near the free end of the resonator. To circumvent this error we employ the second flexural bending mode. This mode exhibits additional frequency peaks while particles pass over the antinode, a point where the frequency shift is insensitive to the lateral position of the particle. We measure polystyrene beads with the first and second modes and confirm that the second mode sensing provides a narrower mass histogram. For 3 μm diameter beads, second mode sensing at the antinode improves the coefficient of variation in buoyant mass from 1.76% to 1.05% for population measurements and from 1.40% to 0.53% for a single trapped particle.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1063/1.3534825
