A New Natural Defense Against Airborne Pathogens
Name
a-new-natural-defense-against-airborne-pathogens.pdf
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1.73 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Edwards, David
Hickey, Anthony
Batycky, Richard
Griel, Lester
Lipp, Michael
Dehaan, Wes
Clarke, Robert
Hava, David
Perry, Jason
Laurenzi, Brendan
Date Issued
July 2020
Journal
QRB Discovery
Publisher
Cambridge University Press (CUP)
Citation
Edwards, David et al. "A New Natural Defense Against Airborne Pathogens." QRB Discovery 1 (July 2020): e5. © 2020 The Author(s)
Version
Final published version
Abstract
We propose the nasal administration of calcium-enriched physiological salts as a new hygienic intervention with possible therapeutic application as a response to the rapid and tenacious spread of COVID-19. We test the effectiveness of these salts against viral and bacterial pathogens in animals and humans. We find that aerosol administration of these salts to the airways diminishes the exhalation of the small particles that face masks fail to filter and, in the case of an influenza swine model, completely block airborne transmission of disease. In a study of 10 human volunteers (5 less than 65 years and 5 older than 65 years), we show that delivery of a nasal saline comprising calcium and sodium salts quickly (within 15 min) and durably (up to at least 6 h) diminishes exhaled particles from the human airways. Being predominantly smaller than 1 μm, these particles are below the size effectively filtered by conventional masks. The suppression of exhaled droplets by the nasal delivery of calcium-rich saline with aerosol droplet size of around 10 μm suggests the upper airways as a primary source of bioaerosol generation. The suppression effect is especially pronounced (99%) among those who exhale large numbers of particles. In our study, we found this high-particle exhalation group to correlate with advanced age. We argue for a new hygienic practice of nasal cleansing by a calcium-rich saline aerosol, to complement the washing of hands with ordinary soap, use of a face mask, and social distancing.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1017/qrd.2020.9
