Writ large: Genomic dissection of the effect of cellular environment on immune response
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nihms819553.pdf
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1.03 MB
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Author(s)
Yosef, N.
Regev, Aviv
Date Issued
October 2016
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Yosef, N. and A. Regev. “Writ Large: Genomic Dissection of the Effect of Cellular Environment on Immune Response.” Science 354, 6308 (October 2016): 64–68 © 2016 American Association for the Advancement of Science
Version
Author's final manuscript
Abstract
Cells of the immune system routinely respond to cues from their local environment and feed back to their surroundings through transient responses, choice of differentiation trajectories, plastic changes in cell state, and malleable adaptation to their tissue of residence. Genomic approaches have opened the way for comprehensive interrogation of such orchestrated responses. Focusing on genomic profiling of transcriptional and epigenetic cell states, we discuss how they are applied to investigate immune cells faced with various environmental cues. We highlight some of the emerging principles on the role of dense regulatory circuitry, epigenetic memory, cell type fluidity, and reuse of regulatory modules in achieving and maintaining appropriate responses to a changing environment.These provide a first step toward a systematic understanding of molecular circuits in complex tissues.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1126/SCIENCE.AAF5453
