Nanowired three-dimensional cardiac patches
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Langer_Nanowired three-dimensional.pdf
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2.3 MB
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Author(s)
Dvir, Tal
Timko, Brian P.
Brigham, Mark D.
Naik, Shreesh R.
Karajanagi, Sandeep S.
Levy, Oren
Jin, Hongwei
Parker, Kevin K.
Kohane, Daniel S.
Langer, Robert S
Date Issued
September 2011
Journal
Nature Nanotechnology
Publisher
Nature Publishing Group
Citation
Dvir, Tal, Brian P. Timko, Mark D. Brigham, Shreesh R. Naik, Sandeep S. Karajanagi, Oren Levy, Hongwei Jin, Kevin K. Parker, Robert Langer, and Daniel S. Kohane. Nanowired Three-dimensional Cardiac Patches. Nature Nanotechnology 6, no. 11 (September 25, 2011): 720-725.
Version
Author's final manuscript
Abstract
Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds1, 2, 3. These biomaterials, which are usually made of either biological polymers such as alginate4 or synthetic polymers such as poly(lactic acid) (PLA)5, help cells organize into functioning tissues, but poor conductivity of these materials limits the ability of the patch to contract strongly as a unit6. Here, we show that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls of alginate and improve electrical communication between adjacent cardiac cells. Tissues grown on these composite matrices were thicker and better aligned than those grown on pristine alginate and when electrically stimulated, the cells in these tissues contracted synchronously. Furthermore, higher levels of the proteins involved in muscle contraction and electrical coupling are detected in the composite matrices. It is expected that the integration of conducting nanowires within three-dimensional scaffolds may improve the therapeutic value of current cardiac patches.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1038/nnano.2011.160
