Population dynamics of DENV-1 genotype V in Brazil is characterized by co-circulation and strain/lineage replacement
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Author(s)
Drumond, Betânia Paiva
Mondini, Adriano
Schmidt, Diane J.
Bosch, Irene
Nogueira, Maurício Lacerda
Date Issued
July 2012
Journal
Archives of Virology
Publisher
Springer Vienna
Citation
Drumond, Betânia Paiva et al. “Population Dynamics of DENV-1 Genotype V in Brazil Is Characterized by Co-Circulation and Strain/lineage Replacement.” Archives of Virology 157.11 (2012): 2061–2073.
Version
Author's final manuscript
Abstract
Following successive outbreaks of dengue fever caused predominantly by dengue virus (DENV) 2 and 3, DENV-1 is now the primary serotype circulating in Brazil. We sequenced and analyzed Brazilian DENV-1 genomes and found that all isolates belong to genotype V and are subdivided into three lineages, which were introduced during four different events. The first introduction occurred in 1984-85, the second in 1997-99, and the third and fourth occurred from 2004 to 2007. These events were associated with an increase in genetic diversity but not with positive selection. Moreover, a potential new recombinant strain derived from two distinct lineages was detected. We demonstrate that the dynamics of DENV-1 in Brazil is characterized by introduction, movement, local evolution, and lineage replacement. This study strengthens the relevance of genotype surveillance in order to identify, trace, and control virus populations circulating in Brazil and Latin America.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s00705-012-1393-9
