Integrated microHall magnetometer to measure the magnetic properties of nanoparticles
Name
nihms915658.pdf
Description
Accepted version
Size
1.44 MB
Format
Unknown
Checksum (MD5)
e1074bb05277459b7fe41a49c44e4ec9
Author(s)
Min, Changwook
Park, Jongmin
Mun, Jae Kyoung
Lim, Yongjun
Min, Jouha
Lim, Jong-Won
Kang, Dong-Min
Ahn, Ho-Kyun
Shin, Tae-Hyun
Cheon, Jinwoo
Date Issued
October 2017
Journal
Lab on a Chip
Publisher
Royal Society of Chemistry (RSC)
Version
Author's final manuscript
Abstract
© 2017 The Royal Society of Chemistry. Magnetic nanoparticles (MNPs) are widely used in biomedical and clinical applications, including medical imaging, therapeutics, and biological sample processing. Rapid characterization of MNPs, notably their magnetic moments, should facilitate optimization of particle synthesis and accelerate assay development. Here, we report a compact and low-cost magnetometer for fast, on-site MNP characterization. Termed integrated microHall magnetometer (iHM), our device was fabricated using standard semiconductor processes: an array of Hall sensors, transistor switches, and amplifiers were integrated into a single chip, thus improving the detection sensitivity and facilitating chip operation. By applying the iHM, we demonstrate versatile magnetic assays. We measured the magnetic susceptibility and moments of MNPs using small sample amounts (∼10 pL), identified different MNP compositions in mixtures, and detected MNP-labeled single cells.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c7lc00934h
