Enantioselective synthesis of pretomanid & investigations of Raman spectroscopy for through-tube monitoring of reactions
Name
1126333540-MIT.pdf
Size
33.88 MB
Format
Adobe PDF
Checksum (MD5)
c25e458dbc82b5a5faee76ed00a5840e
Author(s)
Tran, Tho Huu.
Advisor(s)
Timothy F. Jamison.
Alternative Title
Enantioselective synthesis of pretomanid and investigations of Raman spectroscopy for through-tube monitoring of reactions
Investigations of Raman spectroscopy for through-tube monitoring of reactions
Date Issued
2019
Publisher
Massachusetts Institute of Technology
Abstract
Chapter 1: Enantioselective Synthesis of Pretomanid [color illustrations] Pretomanid is a potential cornerstone active pharmaceutical ingredient for the treatment of tuberculosis (TB). It is found in several advanced clinical trials and can possibly treat all forms of TB. In this report, we discuss the development of a novel synthesis of pretomanid through a selective epoxide-opening cyclization and late-stage nitration. This route offers a new strategy to access the core of pretomanid and avoids the necessity of the explosive starting material. Chapter 2: Investigations of Raman Spectroscopy for Through-Tube Monitoring of Reactions [color illustrations] Continuous-flow chemistry has seen expansive growth and thus requires powerful new analytical techniques. The current commonly-used analytics involve inline analysis at a single point, which can hinder analysis. In this report, we demonstrate the utility of the MarqMetrix TouchRaman probe for reaction monitoring through a continuous-flow reactor. The reactions studied were ring-closing metathesis, benzyne generation, and ketene generation.
Description
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019
Cataloged from PDF version of thesis.
Includes bibliographical references.
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
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