Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
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Regev_Intrathymic programming.pdf
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Author(s)
Narayan, Kavitha
Sylvia, Katelyn E.
Malhotra, Nidhi
Yin, Catherine C.
Martens, Gregory
Vallerskog, Therese
Kornfeld, Hardy
Xiong, Na
Cohen, Nadia R.
Brenner, Michael B.
Date Issued
April 2012
Journal
Nature Immunology
Publisher
Nature Publishing Group
Citation
Narayan, Kavitha, Katelyn E Sylvia, Nidhi Malhotra, Catherine C Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, et al. “Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes.” Nature Immunology 13, no. 5 (April 1, 2012): 511-518.
Version
Author's final manuscript
Abstract
Innate γδ T cells function in the early phase of immune responses. Although innate γδ T cells have often been studied as one homogenous population, they can be functionally classified into effector subsets on the basis of the production of signature cytokines, analogous to adaptive helper T cell subsets. However, unlike the function of adaptive T cells, γδ effector T cell function correlates with genomically encoded T cell antigen receptor (TCR) chains, which suggests that clonal TCR selection is not the main determinant of the differentiation of γδ effector cells. A high-resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated on the basis of use of the TCR γ-chain or δ-chain indicated the existence of three separate subtypes of γδ effector cells in the thymus. The immature γδ subsets were distinguished by unique transcription-factor modules that program effector function.
Description
PMC 2012 November 01
MIT Department
Massachusetts Institute of Technology. Department of Biology
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DOI of Published Version
https://doi.org/10.1038/ni.2247
