Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo
Name
1-s2.0-S1525001620300538-main.pdf
Description
Published version
Size
3.01 MB
Format
Unknown
Checksum (MD5)
dd6779e545d9b50f1340465b872bedac
Author(s)
Leboeuf, Dominique
Abakumova, Tatiana
Prikazchikova, Tatiana
Rhym, Luke
Anderson, Daniel G
Zatsepin, Timofei S
Piatkov, Konstantin I
Date Issued
January 2020
Journal
Molecular Therapy
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The American Society of Gene and Cell Therapy With the use of a small interfering RNA (siRNA)-mediated approach for selective downregulation of the Arg/N-degron pathway in a murine hepatocellular carcinoma model, Leboeuf et al. demonstrated potentiated action of chemotherapy. Since components of this pathway are ubiquitously expressed, targeting the N-degron pathway has the potential to increase effectiveness of therapy in many cancer types.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.YMTHE.2020.01.021
