Synthetic Biology of Antimicrobial Discovery
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Lu_Synthetic biology.pdf
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1.26 MB
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Adobe PDF
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Author(s)
Zakeri, Bijan
Lu, Timothy K.
Date Issued
November 2012
Journal
ACS Synthetic Biology
Publisher
American Chemical Society (ACS)
Citation
Zakeri, Bijan, and Timothy K. Lu. “Synthetic Biology of Antimicrobial Discovery.” ACS Synthetic Biology 2, no. 7 (July 19, 2013): 358–372.
Version
Author's final manuscript
Abstract
Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug-resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Synthetic Biology Center
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/sb300101g
