Sirtuin deacetylases in neurodegenerative diseases of aging
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Guarente_Sirtuin deacetylases.pdf
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2.06 MB
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Adobe PDF
Checksum (MD5)
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Author(s)
Herskovits, A. Zara
Guarente, Leonard Pershing
Date Issued
May 2013
Journal
Cell Research
Publisher
Nature Publishing Group
Citation
Herskovits, Adrianna Z, and Leonard Guarente. “Sirtuin Deacetylases in Neurodegenerative Diseases of Aging.” Cell Research 23.6 (2013): 746–758.
Version
Author's final manuscript
Abstract
Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Sirtuin enzymes are potential therapeutic targets in a variety of human diseases including cancer, diabetes, inflammatory disorders and neurodegenerative disease. Modulation of sirtuin activity has been shown to impact the course of several aggregate-forming neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and spinal and bulbar muscular atrophy. Sirtuins can influence the progression of neurodegenerative disorders by modulating transcription factor activity and directly deacetylating proteotoxic species. Here, we describe sirtuin protein targets in several aggregate-forming neurodegenerative diseases and discuss the therapeutic potential of compounds that modulate sirtuin activity in these disorders.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License
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DOI of Published Version
https://doi.org/10.1038/cr.2013.70
