Entorhinal–hippocampal neuronal circuits bridge temporally discontiguous events
Name
Kitamura-2015-Entorhinal-hippocamp.pdf
Size
510.6 KB
Format
Adobe PDF
Checksum (MD5)
3d1abab86abc34e2dd3210b39dd0b2f9
Author(s)
Kitamura, Takashi
MacDonald, Christopher J
Tonegawa, Susumu
Date Issued
September 2015
Journal
Learning & Memory
Publisher
Cold Spring Harbor Laboratory Press
Citation
Kitamura, Takashi, Christopher J. Macdonald, and Susumu Tonegawa. “Entorhinal–hippocampal Neuronal Circuits Bridge Temporally Discontiguous Events.” Learning & Memory 22, no. 9 (August 18, 2015): 438–443.
Version
Final published version
Abstract
The entorhinal cortex (EC)–hippocampal (HPC) network plays an essential role for episodic memory, which preserves spatial and temporal information about the occurrence of past events. Although there has been significant progress toward understanding the neural circuits underlying the spatial dimension of episodic memory, the relevant circuits subserving the temporal dimension are just beginning to be understood. In this review, we examine the evidence concerning the role of the EC in associating events separated by time—or temporal associative learning—with emphasis on the function of persistent activity in the medial entorhinal cortex layer III (MECIII) and their direct inputs into the CA1 region of HPC. We also discuss the unique role of Island cells in the medial entorhinal cortex layer II (MECII), which is a newly discovered direct feedforward inhibitory circuit to CA1. Finally, we relate the function of these entorhinal cortical circuits to recent findings concerning hippocampal time cells, which may collectively activate in sequence to bridge temporal gaps between discontiguous events in an episode.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
Terms of Use
Creative Commons Attribution-NonCommercial 4.0 International
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1101/lm.038687.115
