Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering
Name
ten.tea.2019.0032.pdf
Description
Published version
Size
15.85 MB
Format
Adobe PDF
Checksum (MD5)
73194154f83abc4569668594fc8f7045
Author(s)
Hoffman, Tyler
Khademhosseini, Ali
Langer, Robert
Date Issued
2019
Journal
Tissue Engineering
Publisher
Mary Ann Liebert Inc
Version
Final published version
Abstract
© Copyright 2019, Mary Ann Liebert, Inc., publishers 2019. In the past 25 years, the tissue engineering field has made incredible strides in developing tangible therapies for patients in need. Applications of the tissue engineering paradigm, involving varying configurations of cells, materials, and biochemical factors, have been explored for their regenerative capacity of virtually all tissue types. The impact and learning opportunities of current tissue engineering that inspired clinical successes are summarized. In addition, challenges associated with the translation and scale-up of therapies and replacements for complex organs, such as the heart and liver, are addressed. Platforms of research thrusts, specifically cell source, materials, fabrication, scalability, and Food and Drug Administration regulatory changes, and their respective innovations are identified for their potential to address these problems. Ideally, through their progress, tissue engineering strategies can be used to create a diverse range of easily accessible patient-specific treatments that more effectively improve quality of life. In this Perspective, we discuss the impact of the past 25 years of tissue engineering on the development of clinical therapies. Based on their success and other significant research accomplishments, platforms of innovation were identified. Their discoveries will enable tissue engineering inspired therapies to meet the requirements necessary for large-scale manufacturing and Food and Drug Administration (FDA) approval for a diverse range of indications.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
10.1089/TEN.TEA.2019.0032
https://doi.org/10.1089/TEN.TEA.2019.0032
