Pathological crystallization of human immunoglobulins
Name
Wang-2012-Pathological Crystallization of Human Immunoglobulins.pdf
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688.78 KB
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Author(s)
Wang, Ying
Lomakin, Aleksey
Hideshima, Teru
Laubach, Jacob P.
Ogun, Olutayo
Richardson, Paul G.
Munshi, Nikhil C.
Anderson, Kenneth C.
Benedek, George B.
Date Issued
July 2012
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Wang, Y. et al. “Pathological Crystallization of Human Immunoglobulins.” Proceedings of the National Academy of Sciences 109.33 (2012): 13359–13361. © 2012 National Academy of Sciences
Version
Final published version
Abstract
Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.
MIT Department
MIT Materials Research Laboratory
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Department of Physics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1211723109
