When bigger is better: the role of polyploidy in organogenesis
Name
When bigger is better.pdf
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518.76 KB
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Adobe PDF
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b897a994b2a3ed4ba8db10544ee28584
Author(s)
Orr-Weaver, Terry L.
Orr-Weaver, Terry
Date Issued
April 2015
Journal
Trends in Genetics
Publisher
Elsevier
Citation
Orr-Weaver, Terry L. “When Bigger Is Better: The Role of Polyploidy in Organogenesis.” Trends in Genetics 31, no. 6 (June 2015): 307–315. © 2015 Elsevier Ltd.
Version
Author's final manuscript
Abstract
Defining how organ size is regulated, a process controlled not only by the number of cells but also by the size of the cells, is a frontier in developmental biology. Large cells are produced by increasing DNA content or ploidy, a developmental strategy employed throughout the plant and animal kingdoms. The widespread use of polyploidy during cell differentiation makes it important to define how this hypertrophy contributes to organogenesis. I discuss here examples from a variety of animals and plants in which polyploidy controls organ size, the size and function of specific tissues within an organ, or the differentiated properties of cells. In addition, I highlight how polyploidy functions in wound healing and tissue regeneration.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.tig.2015.03.011
