Contraction blocking during wound healing of three injured organs leads to absence of scar and induction of regeneration
Name
4471-13-10599051-4-10-20231008.pdf
Description
Published version
Size
3.23 MB
Format
Adobe PDF
Checksum (MD5)
4071b57cff0df9fc2ffa918227f769d3
Author(s)
Yannas, Ioannis
Date Issued
2023
Journal
Medical Research Archives
Publisher
Knowledge Enterprise Journals
Citation
Yannas, Ioannis. 2023. "Contraction blocking during wound healing of three injured organs leads to absence of scar and induction of regeneration." Medical Research Archives, 11 (9).
Version
Final published version
Abstract
We report the central role of mechanical contraction in healing of wounds in animal models, as well as in humans. Our evidence has been collected from studies of excised skin wounds as well as with the transected peripheral neve and the excised conjunctiva. We have observed that, following blocking of contraction, wounds in our animal models close by regeneration of the injured tissues. We review the mechanism of contraction blocking and tissue regeneration when wounds are grafted with a highly porous Type I collagen scaffold, named dermis regeneration template (DRT) which is required for inducing regeneration.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.18103/mra.v11i9.4471
