Copper-Catalyzed Trifluoromethylation of Unactivated Olefins
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Buchwald_Copper-catalyzed.pdf
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Author(s)
Parsons, Andrew T.
Buchwald, Stephen Leffler
Date Issued
August 2011
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Parsons, Andrew T., and Stephen L. Buchwald. “Copper-Catalyzed Trifluoromethylation of Unactivated Olefins.” Angewandte Chemie International Edition 50, no. 39 (September 19, 2011): 9120-9123.
Version
Author's final manuscript
Abstract
Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/anie.201104053
