A New Class of Easily Activated Palladium Precatalysts for Facile C−N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides
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Buchwald_A New class.pdf
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Author(s)
Biscoe, Mark R.
Fors, Brett P.
Buchwald, Stephen Leffler
Date Issued
May 2008
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society
Citation
Biscoe, Mark R., Brett P. Fors, and Stephen L. Buchwald. “A New Class of Easily Activated Palladium Precatalysts for Facile C−N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides.” Journal of the American Chemical Society 130, no. 21 (May 2008): 6686–6687.
Version
Final published version
Abstract
A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally stable, are easily activated under normal reaction conditions at or below room temperature, and ensure the formation of the highly active monoligated Pd(0) complex necessary for oxidative addition. The use of these precatalysts as a convenient source of LPd(0) in C−N cross-coupling reactions is explored. The reactivity that is demonstrated in this study is unprecedented in palladium chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ja801137k
