Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting
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Hammond_Highly stable.pdf
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Author(s)
Poon, Zhiyong
Lee, Jung Ah
Huang, Shenwen
Prevost, Richard J.
Hammond, Paula T.
Date Issued
September 2010
Journal
Nanomedicine: Nanotechnology, Biology and Medicine
Publisher
Elsevier
Citation
Poon, Zhiyong, Jung Ah Lee, Shenwen Huang, Richard J. Prevost, and Paula T. Hammond. “Highly Stable, Ligand-Clustered ‘patchy’ Micelle Nanocarriers for Systemic Tumor Targeting.” Nanomedicine: Nanotechnology, Biology and Medicine 7, no. 2 (April 2011): 201–209.
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Author's final manuscript
Abstract
A novel linear-dendritic block copolymer has been synthesized and evaluated for targeted delivery. The use of the dendron as the micellar exterior block in this architecture allows the presentation of a relatively small quantity of ligands in clusters for enhanced targeting, thus maintaining a long circulation time of these “patchy” micelles. The polypeptide linear hydrophobic block drives formation of micelles that carry core-loaded drugs, and their unique design gives them extremely high stability in vivo. We have found that these systems lead to extended time periods of increased accumulation in the tumor (up to 5 days) compared with nontargeted vehicles. We also demonstrate a fourfold increase in efficacy of paclitaxel when delivered in the targeted nanoparticle systems, while significantly decreasing in vivo toxicity of the chemotherapy treatment.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.nano.2010.07.008
