The Wanderlust of Newborn Neocortical Interneurons
Name
Scott-2009-The Wanderlust of Ne.pdf
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52.13 KB
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Author(s)
Sanjana, Neville E.
Scott, Benjamin Barnett
Date Issued
June 2009
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Scott, Benjamin B, and Neville E Sanjana. “The Wanderlust of Newborn Neocortical Interneurons.” J. Neurosci. 29.22 (2009): 7114-7115. © 2009 The Society for Neuroscience
Version
Final published version
Abstract
For proper formation of the cerebral cortex, immature neurons must travel from their birthplace within the walls of the lateral ventricle to their final destinations throughout the brain. This process requires active migration over long distances and failure of neurons to properly migrate carries serious consequences for the organism. In humans, disruption of the genes that direct neuronal migration can cause severe mental retardation or even death (Gleeson and Walsh, 2000Go). Understanding the mechanisms for neuronal circuit formation will lead to a better understanding of basic design principles for brain architecture and the development of potential therapies for the treatment of brain disorders caused by aberrant migration.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1523/jneurosci.1624-09.2009
