Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

Boyden, Edward

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

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Author(s)

Boyden, Edward

Date Issued

November 14, 2019

Journal

Cell

Publisher

Elsevier BV

Version

Final published version

Abstract

A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.

MIT Department

Massachusetts Institute of Technology. Media Laboratory

Terms of Use

Creative Commons Attribution-NonCommercial-NoDerivs License

http://creativecommons.org/licenses/by-nc-nd/4.0/

Persistent DSpace Link

https://hdl.handle.net/1721.1/136528.2

DOI of Published Version

https://doi.org/10.1016/j.cell.2019.10.026