Conservation, acquisition, and functional impact of sex-biased gene expression in mammals
Name
nihms-1058814.pdf
Description
Accepted version
Size
2.13 MB
Format
Adobe PDF
Checksum (MD5)
8eb8d96bdc1f456e19c087d260499981
Author(s)
Naqvi, Sahin
Godfrey, Alexander K.
Hughes, Jennifer F.
Goodheart, Mary L.
Page, David C.
Date Issued
July 2019
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Naqvi, Sahin et al. “Conservation, acquisition, and functional impact of sex-biased gene expression in mammals.” Science 365 (2019): aaw7317 © 2019 The Author(s)
Version
Author's final manuscript
Abstract
Sex differences abound in human health and disease, as they do in other mammals used as models. The extent to which sex differences are conserved at the molecular level across species and tissues is unknown. We surveyed sex differences in gene expression in human, macaque, mouse, rat, and dog, across 12 tissues. In each tissue, we identified hundreds of genes with conserved sex-biased expression-findings that, combined with genomic analyses of human height, explain ∼12% of the difference in height between females and males. We surmise that conserved sex biases in expression of genes otherwise operating equivalently in females and males contribute to sex differences in traits. However, most sex-biased expression arose during the mammalian radiation, which suggests that careful attention to interspecies divergence is needed when modeling human sex differences.
MIT Department
Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/SCIENCE.AAW7317
