The Boston retinal prosthesis a 15-channel hermetic wireless neural stimulator
Name
Kelly-2009-The Boston retinal prosthesis a 15-channel hermetic wireless neural stimulator.pdf
Size
1.45 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Wyatt, John L.
Cogan, Stuart F.
Theogarajan, Luke S.
Chen, Jinghua
Kelly, Shawn K.
Shire, Douglas B.
Doyle, Patrick S.
Gingerich, Marcus D.
Drohan, William A.
Rizzo, Joseph F.
Date Issued
November 2010
Journal
2nd International Symposium on Applied Sciences in Biomedical and Communication Technologies, 2009. ISABEL 2009
Publisher
Institute of Electrical and Electronics Engineers
Citation
Kelly, S.K. et al. “The Boston retinal prosthesis: A 15-channel hermetic wireless neural stimulator.” Applied Sciences in Biomedical and Communication Technologies, 2009. ISABEL 2009. 2nd International Symposium on. 2009. 1-6. ©2010 Institute of Electrical and Electronics Engineers.
Version
Final published version
Abstract
A miniaturized, hermetically-encased, wirelessly-operated retinal prosthesis has been developed for pre-clinical studies in Yucatan minipig animal models. The prosthesis attaches conformally to the outside of the eye and drives a microfabricated thin-film polyimide stimulating electrode array with sputtered iridium oxide electrodes. This array is implanted in the subretinal space using a specially-designed ab externo surgical technique that uses the retina to hold the array in place while leaving the bulk of the prosthesis outside the eye. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete circuit components. Feedthroughs from the case connect to secondary power- and data-receiving coils. In addition, long-term in vitro pulse testing was performed on the electrodes to ensure that their lifetime would match that of the hermetic case. The final assembly was tested in vitro to verify wireless operation of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation pulse strength, duration and frequency were programmed wirelessly using a custom graphical user interface. Operation of the retinal implant has been verified in vivo in two pigs for up to five and a half months by measuring stimulus artifact on the eye surface using a contact lens electrode.
Subjects
bioelectric potentials
biomedical electrodes
biomedical engineering
integrated circuit design
iridium
neuromuscular stimulation
telemetry
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/ISABEL.2009.5373638
