The effects of particle size of collagen and mold material on the pore structure of freeze-dried collagen-GAG scaffolds
Name
191698827-MIT.pdf
Description
Full printable version
Size
1.82 MB
Format
Adobe PDF
Checksum (MD5)
0176ddedc77fcab71a15f49a3f693ca5
Author(s)
Chan, Jenny K. (Jenny Kamjun)
Advisor(s)
Myron Spector.
Date Issued
2007
Publisher
Massachusetts Institute of Technology
Abstract
This study was performed to determine whether the particle size of the starting collagen powder or the material of molds used during freeze-drying had effects on the scaffold pore structure. Collagen particles were separated by size prior to slurry making using a sieve with 1000 [mu]m openings, and scaffolds were made using both metal pans and polysulfone trays, two commonly used molds. The mean and variation of pore diameter and interconnectivity of freeze-dried scaffolds were compared to determine the relationship between particle size or mold material and the resulting pore diameter, for a specific same freeze-drying condition (viz., temperature). Knowing these relationships will permit a better control of pore size during fabrication, allowing researchers to design scaffolds with greater predictability and specificity.
Description
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.
Includes bibliographical references (p. 25).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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