Modeling hepatitis C virus infection using human induced pluripotent stem cells
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Bhatia_Modeling hepatitis.pdf
Size
1.87 MB
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Adobe PDF
Checksum (MD5)
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Author(s)
Schwartz, Robert E.
Trehan, Kartik
Andrus, Linda
Sheahan, Timothy P.
Ploss, Alexander
Duncan, Stephen A.
Rice, Charles M.
Bhatia, Sangeeta N
Date Issued
January 2012
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Schwartz, R. E., K. Trehan, L. Andrus, T. P. Sheahan, A. Ploss, S. A. Duncan, C. M. Rice, and S. N. Bhatia. “Modeling Hepatitis C Virus Infection Using Human Induced Pluripotent Stem Cells.” Proceedings of the National Academy of Sciences 109, no. 7 (February 14, 2012): 2544–2548.
Version
Final published version
Abstract
Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1121400109
