Normalization of mechanical power to anthropometric indices: impact on its association with mortality in critically ill patients
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Author(s)
Serpa Neto, Ary
Deliberato, Rodrigo O
Johnson, Alistair Edward William
Pollard, Tom Joseph
Celi, Leo Anthony G.
Pelosi, Paolo
Gama de Abreu, Marcelo
Schultz, Marcus J
Date Issued
October 2019
Publisher
Springer Berlin Heidelberg
Version
Author's final manuscript
Abstract
Recently, we showed how mechanical power (MP) was associated with patient–centered outcomes in two large prospective cohorts of critically ill patients under invasive ventilation [1]. Normalization of MP, e.g., to the predicted body weight (PBW), has been put forward [2]. One recent paper showed MP normalized to PBW to be a better predictor of mortality than the absolute MP, at least in ARDS patients [3]. We here report the results of a posthoc analysis of the datasets used in our abovementioned publication [1]. We tested the hypothesis that MP normalized to three common anthropometric indexes, i.e., PBW, body mass index (BMI), and body surface area (BSA) are better predictors of in–hospital mortality than absolute MP in critically ill patients under invasive ventilation.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard--MIT Program in Health Sciences and Technology. Laboratory for Computational Physiology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s00134-019-05794-9
