Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings
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Author(s)
Shah, Nisarg J.
Hyder, Md Nasim
Moskowitz, Joshua Seth
Quadir, Mohiuddin Abdul
Morton, Stephen Winford
Seeherman, Howard J.
Padera, Robert F.
Spector, Myron
Hammond, Paula T
Date Issued
June 2013
Journal
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Shah, N. J., M. N. Hyder, J. S. Moskowitz, M. A. Quadir, S. W. Morton, H. J. Seeherman, R. F. Padera, M. Spector, and P. T. Hammond. “Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings.” Science Translational Medicine 5, no. 191 (June 26, 2013): 191ra83–191ra83.
Version
Author's final manuscript
Abstract
The functional success of a biomedical implant critically depends on its stable bonding with the host tissue. Aseptic implant loosening accounts for more than half of all joint replacement failures. Various materials, including metals and plastic, confer mechanical integrity to the device, but often these materials are not suitable for direct integration with the host tissue, which leads to implant loosening and patient morbidity. We describe a self-assembled, osteogenic, polymer-based conformal coating that promotes stable mechanical fixation of an implant in a surrogate rodent model. A single modular, polymer-based multilayered coating was deposited using a water-based layer-by-layer approach, by which each element was introduced on the surface in nanoscale layers. Osteoconductive hydroxyapatite (HAP) and osteoinductive bone morphogenetic protein–2 (BMP-2) contained within the nanostructured coating acted synergistically to induce osteoblastic differentiation of endogenous progenitor cells within the bone marrow, without indications of a foreign body response. The tuned release of BMP-2, controlled by a hydrolytically degradable poly(β-amino ester), was essential for tissue regeneration, and in the presence of HAP, the modular coating encouraged the direct deposition of highly cohesive trabecular bone on the implant surface. In vivo, the bone-implant interfacial tensile strength was significantly higher than standard bioactive bone cement, did not fracture at the interface, and had long-term stability. Collectively, these results suggest that the multilayered coating system promotes biological fixation of orthopedic and dental implants to improve surgical outcomes by preventing loosening and premature failure.
MIT Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Laboratory for Manufacturing and Productivity
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/scitranslmed.3005576
