Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells
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van Oudenaarden_Circadian gating.pdf
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Checksum (MD5)
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Author(s)
Pando, Bernardo Fabian
Dong, Guogang
Golden, Susan S.
van Oudenaarden, Alexander
Yang, Qiong, Ph. D. Massachusetts Institute of Technology
Date Issued
March 2010
Journal
Science
Publisher
American Association for the Advancement of Science
Citation
Yang, Q., B. F. Pando, G. Dong, S. S. Golden, and A. van Oudenaarden. “Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells.” Science 327, no. 5972 (March 18, 2010): 1522-1526.
Version
Author's final manuscript
Abstract
Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Synechococcus elongatus and fit the data to a model to determine when cell cycle progression slows as a function of circadian and cell cycle phases. We infer that cell cycle progression in cyanobacteria slows during a specific circadian interval but is uniform across cell cycle phases. Our model is applicable to the quantification of the coupling between biological oscillators in other organisms.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Physics
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1126/science.1181759
