Reciprocity of Cell Mechanics with Extracellular Stimuli: Emerging Opportunities for Translational Medicine
Name
nihms-1825469.pdf
Description
Accepted version
Size
2.42 MB
Format
Adobe PDF
Checksum (MD5)
e316e57be0da863d83cb8dcd575aebb0
Author(s)
Li, Yiwei
Wong, Ian Y
Guo, Ming
Date Issued
September 2022
Journal
Small
Publisher
Wiley
Citation
Li, Yiwei, Wong, Ian Y and Guo, Ming. 2022. "Reciprocity of Cell Mechanics with Extracellular Stimuli: Emerging Opportunities for Translational Medicine." Small, 18 (36).
Version
Author's final manuscript
Abstract
AbstractHuman cells encounter dynamic mechanical cues in healthy and diseased tissues, which regulate their molecular and biophysical phenotype, including intracellular mechanics as well as force generation. Recent developments in bio/nanomaterials and microfluidics permit exquisitely sensitive measurements of cell mechanics, as well as spatiotemporal control over external mechanical stimuli to regulate cell behavior. In this review, the mechanobiology of cells interacting bidirectionally with their surrounding microenvironment, and the potential relevance for translational medicine are considered. Key fundamental concepts underlying the mechanics of living cells as well as the extracelluar matrix are first introduced. Then the authors consider case studies based on 1) microfluidic measurements of nonadherent cell deformability, 2) cell migration on micro/nano‐topographies, 3) traction measurements of cells in three‐dimensional (3D) matrix, 4) mechanical programming of organoid morphogenesis, as well as 5) active mechanical stimuli for potential therapeutics. These examples highlight the promise of disease diagnosis using mechanical measurements, a systems‐level understanding linking molecular with biophysical phenotype, as well as therapies based on mechanical perturbations. This review concludes with a critical discussion of these emerging technologies and future directions at the interface of engineering, biology, and medicine.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/smll.202107305
