Characterization of AP-MALDI and ESI for a differential mobility spectrometer
Name
62221592-MIT.pdf
Description
Full printable version
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13.68 MB
Format
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Checksum (MD5)
cc5c4048ffd2e77f4b090839ad6c6e4e
Author(s)
Agrawal, Priya
Advisor(s)
Cristina E. Davis.
Alternative Title
Characterization of Atmospheric Pressure Matrix Assisted Laser Desorption Ionization and Electrospray Ionization for a differential mobility spectrometer
Date Issued
2005
Publisher
Massachusetts Institute of Technology
Abstract
The following thesis entails the construction, testing, modification, and analysis of two systems that couple sample ion introduction methods with a Differential Mobility Spectrometer (DMS). The sample ionization methods used with a custom designed interface for the DMS were Electrospray Ionization (ESI) and Atmospheric Pressure Matrix Assisted Laser Desorption Ionization (AP-MALDI). In addition to system development, Fourier transform and decision tree analyses were explored as alternatives to lead-cluster mapping and genetic algorithms for analyzing and classifying data produced by the systems for large biomolecules. Findings from testing and experiments using the prototype system have led to a second generation design of the interface. Results from data analysis have also provided new insights into different methods for classifying data whose form changes drastically for different sample introduction methods.
Description
Thesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.
Includes bibliographical references (leaves 114-116).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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