miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
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Sur_Mir-132 an experience.pdf
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Author(s)
Mellios, Nikolaos
Sugihara, Hiroki
Castro, Jorge
Banerjee, Abhishek
Le, Chuong N.
Kumar, Arooshi R.
Crawford, Benjamin
Strathmann, Julia
Tropea, Daniela
Edbauer, Dieter
Date Issued
September 2011
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Mellios, Nikolaos, Hiroki Sugihara, Jorge Castro, Abhishek Banerjee, Chuong Le, Arooshi Kumar, Benjamin Crawford, et al. “miR-132, an Experience-Dependent microRNA, Is Essential for Visual Cortex Plasticity.” Nat Neurosci 14, no. 10 (September 4, 2011): 1240–1242.
Version
Author's final manuscript
Abstract
Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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DOI of Published Version
https://doi.org/10.1038/nn.2909
