Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors
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Author(s)
Pluth, Michael D.
Tomat, Elisa
Lippard, Stephen J.
Date Issued
July 2011
Journal
Annual Review of Biochemistry
Publisher
Annual Reviews
Citation
Pluth, Michael D., Elisa Tomat, and Stephen J. Lippard. “Biochemistry of Mobile Zinc and Nitric Oxide Revealed by Fluorescent Sensors.” Annual Review of Biochemistry 80.1 (2011): 333–355.
Version
Author's final manuscript
Abstract
Biological mobile zinc and nitric oxide (NO) are two prominent examples of inorganic compounds involved in numerous signaling pathways in living systems. In the past decade, a synergy of regulation, signaling, and translocation of these two species has emerged in several areas of human physiology, providing additional incentive for developing adequate detection systems for Zn(II) ions and NO in biological specimens. Fluorescent probes for both of these bioinorganic analytes provide excellent tools for their detection, with high spatial and temporal resolution. We review the most widely used fluorescent sensors for biological zinc and nitric oxide, together with promising new developments and unmet needs of contemporary Zn(II) and NO biological imaging. The interplay between zinc and nitric oxide in the nervous, cardiovascular, and immune systems is highlighted to illustrate the contributions of selective fluorescent probes to the study of these two important bioinorganic analytes.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1146/annurev-biochem-061009-091643
