Demonstration of Triband Multi-Focal Imaging with Optical Coherence Tomography
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applsci-08-02395.pdf
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Author(s)
Nam, Ahhyun Stephanie
Ren, Jian
Bouma, Brett E.
Vakoc, Benjamin J.
Nam, Ahhyun
Bouma, Brett E
Vakoc, Benjamin
Date Issued
November 2018
Journal
Applied Sciences
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Nam, Ahhyun et al. "Demonstration of Triband Multi-Focal Imaging with
Optical Coherence Tomography." Applied Sciences 8, 12 (November 2018): 2395 © 2018 The Authors
Version
Final published version
Abstract
We demonstrate an extended depth of focus optical coherence tomography (OCT) system based on the use of chromatic aberration to create displaced focal planes in the sample. The system uses a wavelength-swept source tuning over three spectral bands and three separate interferometers, each of which interfaces to a single illumination/collection fiber. The resulting three imaged volumes are merged in post-processing to generate an image with a larger depth of focus than is obtained from each band individually. The improvements are demonstrated in structural imaging of a porous phantom and a lipid-cleared murine brain, and by angiographic imaging of human skin. By using a coaxial approach with Gaussian beams, this approach enables an extended focus with relatively simple microscope optics and data-merging algorithms. Keywords: optical coherence tomography; multi-focal imaging; chromatic focal shift
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.3390/app8122395
