Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders
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Sur_Genes, circuits.pdf
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1.01 MB
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6d08b95ccfc26912953089d7718372b2
Author(s)
Sahin, Mustafa
Sur, Mriganka
Date Issued
July 20, 2016
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Sahin, Mustafa, and Mriganka Sur. “Genes, Circuits, and Precision Therapies for Autism and Related Neurodevelopmental Disorders.” Science 350, no. 6263 (October 15, 2015): aab3897–aab3897.
Version
Author's final manuscript
Abstract
Research in the genetics of neurodevelopmental disorders such as autism suggests that several hundred genes are likely risk factors for these disorders. This heterogeneity presents a challenge and an opportunity at the same time. Although the exact identity of many of the genes remains to be discovered, genes identified to date encode proteins that play roles in certain conserved pathways: protein synthesis, transcriptional and epigenetic regulation, and synaptic signaling. The next generation of research in neurodevelopmental disorders must address the neural circuitry underlying the behavioral symptoms and comorbidities, the cell types playing critical roles in these circuits, and common intercellular signaling pathways that link diverse genes. Results from clinical trials have been mixed so far. Only when we can leverage the heterogeneity of neurodevelopmental disorders into precision medicine will the mechanism-based therapeutics for these disorders start to unlock success.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1126/science.aab3897
