J Waves of Osborn Revisited
Name
nihms732357.pdf
Size
132.74 KB
Format
Adobe PDF
Checksum (MD5)
d229d619bc14b0903e0bb18e58c40f8d
Author(s)
Joynt, Karen
Edelman, Elazer R
Date Issued
May 2010
Journal
Journal of the American College of Cardiology
Publisher
Elsevier
Citation
Edelman, Elazer R., and Joynt, Karen. “J Waves of Osborn Revisited.” Journal of the American College of Cardiology 55, 20 (May 2010): 2287 © 2010 American College of Cardiology Foundation
Version
Author's final manuscript
Abstract
In 1953, Joseph Osborn examined the physiologic effects of hypothermia and defined typical associated changes in the electrocardiogram (ECG), now known as J waves of Osborn. There is a subtlety, however: Osborn's J waves were absent in hypothermic animals whose pH was maintained via mechanical ventilation. Osborn wrote: “We regard this as evidence that the ECG changes … may not be associated with the low temperature directly, but rather may be more closely associated with faulty elimination of CO2under hypothermic conditions” (1).
This principle is illustrated in a 64-year-old man who presented hypothermic to 92°F and profoundly acidemic (pH 7.03) after cardiac arrest. Striking J waves are evident on initial ECG (A). Controlled cooling was initiated; hypothermia was maintained to preserve brain function. Intubation and resuscitation restored bicarbonate, carbon dioxide concentrations, and pH. At pH 7.33, although body temperature was identical at 92°F, the J waves had resolved (B).
MIT Department
Institute for Medical Engineering and Science
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.jacc.2009.06.071
