Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
Name
s41514-020-00049-0.pdf
Description
Published version
Size
2.36 MB
Format
Adobe PDF
Checksum (MD5)
99ef09509bb8394c0fca2d28ecdedb72
Author(s)
Peng, Weng Kung
Chen, Lan
Boehm, Bernhard O.
Han, Jongyoon
Loh, Tze Ping
Date Issued
October 2020
Journal
npj Aging and Mechanisms of Disease
Publisher
Springer Science and Business Media LLC
Citation
Peng, Weng Kung et al. "Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system." npj Aging and Mechanisms of Disease 6, 1 (October 2020): 11 © 2020 The Author(s)
Version
Final published version
Abstract
Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox states of blood using a point-of-care NMR system. Various redox states of the hemoglobin were mapped out using the newly proposed (pseudo) two-dimensional map known as T1–T2 magnetic state diagram. We exploit the fact that oxidative stress changes the subtle molecular motion of water proton in the blood, and thus inducing a measurable shift in magnetic resonance relaxation properties. We demonstrated the clinical utilities of this technique to rapidly stratify diabetes subjects based on their oxidative status in conjunction to the traditional glycemic level to improve the patient stratification and thus the overall outcome of clinical diabetes care and management.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/s41514-020-00049-0
