Antrodia cinnamomea Residual Biomass-Based Hydrogel as a Novel UV-Protective and Antimicrobial Wound-Healing Dressing for Biomedical Use
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ijms-26-04496-v2.pdf
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Author(s)
Xu, Chunyuhang
Chen, Siyu
Liu, Tiange
Zhu, Haowen
Kuo, Chien-Liang
Zhou, Zhuoyu
Chen, Guo
Chin, Fion Wei Lin
Yang, Xin
Huang, Dejian
Date Issued
May 8, 2025
Journal
International Journal of Molecular Sciences
Publisher
Multidisciplinary Digital Publishing Institute
Citation
International Journal of Molecular Sciences 26 (10): 4496 (2025)
Version
Final published version
Abstract
Antrodia cinnamomea is widely known for its bioactive properties, particularly in
anti-cancer, anti-inflammatory, and antibacterial areas. Despite the full use of the bioactive
compounds from its fruiting body, high-value residues remain largely underexploited. This
study presents a novel one-pot gel formation method, utilizing cinnamomea cellulose-riched
residues to create hydrogels as an effective wound-healing dressing. The hydrogels derived
from these residues show desirable properties, including non-drying characteristics, antibacterial activity against Staphylococcus aureus ATCC 1768, and cytocompatibility. Residual
bioactive compounds, such as Antcin-K, Dehydroeburicoic acid, and (25S,R)-Antcin H,
were identified in the residues, adding to the hydrogel’s efficacy. A UVB irradiation model
was employed to evaluate the protective effects of the residues on UVB-damaged HaCaT
skin cell lines, with an IC50 of 0.045 mg/mL. The results indicated that A. cinnamomea
residue extracts reduced the upregulation of MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9
proteins caused by UVB exposure, suggesting high UV-protective activity. Additionally,
antibacterial tests on Staphylococcus aureus strains, including Staphylococcus ATTC 1768,
showed promising results, with inhibition zones ranging from 10.64 to 12.11 mm. In summary, Antrodia cinnamomea residue hydrogels combine UV protection with antimicrobial
activity, making them a promising candidate for medical applications, particularly as a
wound-healing dressing.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.3390/ijms26104496
