Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin
Name
1126333828-MIT.pdf
Size
41.9 MB
Format
Adobe PDF
Checksum (MD5)
1cd9a3c3bfbc0ac1295f74302f79fd65
Author(s)
Weber, Jessica M.(Jessica Marie)
Advisor(s)
Timothy F. Jamison.
Date Issued
2019
Publisher
Massachusetts Institute of Technology
Abstract
[color illustrations] We introduce a new class of bench-stable N-heterocyclic carbene nickel precatalysts for homogeneous nickel-catalysis. The nickel(II) complexes are readily activated to Ni⁰ in situ under mild conditions, via a proposed Heck-type mechanism. The precatalysts are able to facilitate carbonyl-ene, hydroalkenylation, and amination reactions. [color illustrations] Herein, we report the synthesis and characterization of a new class of air- and moisture-stable triphenylphosphine nickel(II) precatalysts, which activate through a Heck-type mechanism. The activity of these precatalysts is demonstrated with a carbonyl-ene coupling reaction.
Description
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019
Cataloged from PDF version of thesis. Page 393 blank.
Includes bibliographical references.
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
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