mTOR Signaling in Growth, Metabolism, and Disease
Name
nihms850540.pdf
Size
1.16 MB
Format
Adobe PDF
Checksum (MD5)
cd9622e332ca868a4ee6a679573b9c88
Author(s)
Saxton, Robert Andrew
Sabatini, David
Date Issued
March 2017
Journal
Cell
Publisher
Elsevier
Citation
Saxton, Robert A., and David M. Sabatini. “mTOR Signaling in Growth, Metabolism, and Disease.” Cell 168, 6 (March 2017): 960–976 © 2017 Elsevier Inc
Version
Author's final manuscript
Abstract
© 2017 Elsevier Inc. The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology. We also highlight how the mTOR signaling network contributes to human disease and discuss the current and future prospects for therapeutically targeting mTOR in the clinic.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELL.2017.02.004
