CVSim: An Open-Source Cardiovascular Simulator for Teaching and Research
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Mark_CVSim an.pdf
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591.79 KB
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Author(s)
Heldt, Thomas
Mukkamala, Ramakrishna
Moody, George B.
Mark, Roger Greenwood
Date Issued
2010
Journal
Open Pacing, Electrophysiology & Therapy Journal
Publisher
Bentham Open
Citation
Heldt, Thomas et al. "CVSim: An Open-Source Cardiovascular Simulator for Teaching and Research." The Open Pacing, Electrophysiology & Therapy Journal, 3 (2010): 45-54.
Version
Final published version
Abstract
CVSim is a lumped-parameter model of the human cardiovascular system that has been developed and used for research and for teaching quantitative physiology courses at MIT and Harvard Medical School since 1984. We present a brief historical background of lumped-parameter cardiovascular system models, followed by an overview of the development of the major versions of CVSim over a 25-year period in our laboratory. We describe the features and differences of four versions of CVSim that are freely available in open-source form via PhysioNet (http://physionet.org). These include a six-compartment cardiovascular model with an arterial baroreflex system, implemented in C for efficiency, with an X-based graphical user interface; a six-compartment model with a more extensive short-term regulatory system and incorporating resting physiologic perturbations, available as a stand-alone MATLAB application; and a pair of elaborated versions consisting of 6- and 21-compartment computational models implemented in C, with a separate and enhanced Java graphical user interface. We conclude with a discussion of the educational and research applications for which we have used CVSim.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Attribution Non-Commercial License
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DOI of Published Version
http://benthamscience.com/open/topetj/V003-SI0001TOPETJ.htm
