Ionic liquid‐mediated transdermal delivery of thrombosis‐detecting nanosensors
Name
Adv Healthcare Materials - 2022 - Bekdemir - Ionic Liquid‐Mediated Transdermal Delivery of Thrombosis‐Detecting Nanosensors.pdf
Description
Published version
Size
2.11 MB
Format
Adobe PDF
Checksum (MD5)
79150c34f70cca25797da8442cf4d780
Author(s)
Bekdemir, Ahmet
Tanner, Eden EL
Kirkpatrick, Jesse
Soleimany, Ava P
Mitragotri, Samir
Bhatia, Sangeeta N
Date Issued
February 19, 2022
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Bekdemir, Ahmet, Tanner, Eden EL, Kirkpatrick, Jesse, Soleimany, Ava P, Mitragotri, Samir et al. 2022. "Ionic liquid‐mediated transdermal delivery of thrombosis‐detecting nanosensors." Advanced Healthcare Materials.
Version
Final published version
Abstract
Blood clotting disorders such as pulmonary embolism is associated with high morbidity and mortality. A large portion of thrombotic events occurs post-operative and after hospital discharge. Therefore, easily applicable, non-invasive and long-term monitoring of thrombosis occurrence is critical for urgent clinical intervention. Here, we propose the use of ionic liquids as a skin transport facilitator to deliver thrombin-sensitive nanosensors that enable prolonged monitoring of pulmonary embolism. Co-formulation of nanosensors with choline and geranic acid (CAGE) ionic liquids demonstrated significant transdermal diffusion into the dermis of the skin and provided sustained release into the blood throughout 72 hours. Upon reaching the systemic circulation, the nanosensors released reporter molecules into the urine by responding to activation of the clotting cascade and retained a diagnostic power for 24 hours in an acute pulmonary embolism mouse model. These results demonstrate a proof-of-concept disease monitoring system that can be topically applied by patients and potentially reducing mortality and high cost of hospitalization. This article is protected by copyright. All rights reserved.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Howard Hughes Medical Institute
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adhm.202102685
