Miniaturized electrochemical sensor modified with aptamers for rapid norovirus detection
Name
Wang N._IEEE NEMS 2016.pdf
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Author(s)
Mani, Kalaivani
Kanhere, Elgar
Wang, Nan
Kitajima, Masaaki
Whittle, Andrew
Triantafyllou, Michael S
Miao, Jianmin
Date Issued
April 2016
Journal
2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Citation
Wang, Nan, Masaaki Kitajima, Kalaivani Mani, Elgar Kanhere, Andrew J. Whittle, Michael S. Triantafyllou, and Jianmin Miao. “Miniaturized Electrochemical Sensor Modified with Aptamers for Rapid Norovirus Detection.” 2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) (April 2016).
Version
Author's final manuscript
Abstract
This paper presents a miniaturized MEMS (microelectromechanical systems)-based electrochemical aptasensor, which utilizes aptamer as the recognition element for simple, sensitive and rapid detection of norovirus. The novelty of this work is integration of micro fabrication technology with aptamers to develop a miniaturized and portable electrochemical sensor for environmental pathogen monitoring. The binding capability between aptamers and on-chip sensing electrodes was investigated and the performance of the proposed MEMS electrochemical aptasensor was evaluated with respect to sensor response to different titers of murine norovirus, a model of human norovirus. This research forms initial basis for the development of an electrochemical MEMS-aptasensor platform and its application for virus detection.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
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DOI of Published Version
https://doi.org/10.1109/NEMS.2016.7758320
