Emerging Evidence of Chromosome Folding by Loop Extrusion
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45.full.pdf
Description
Published version
Size
638.63 KB
Format
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Checksum (MD5)
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Author(s)
Fudenberg, Geoffrey
Abdennur, Nezar Alexander
Imakaev, Maxim
Goloborodko, Anton
Mirny, Leonid A.
Date Issued
2017
Journal
Cold Spring Harbor Symposia on Quantitative Biology
Publisher
Cold Spring Harbor Laboratory
Citation
Fudenberg, Geoffrey et al. "Emerging Evidence of Chromosome Folding by Loop Extrusion." Cold Spring Harbor Symposia on Quantitative Biology 82 (2017): 45-54 ©2017 The Author(s)
Version
Final published version
Abstract
Chromosome organization poses a remarkable physical problem with many biological consequences: How can molecular interactions between proteins at the nanometer scale organize micron-long chromatinized DNA molecules, insulating or facilitating interactions between specific genomic elements? The mechanism of active loop extrusion holds great promise for explaining interphase and mitotic chromosome folding, yet remains difficult to assay directly. We discuss predictions from our polymer models of loop extrusion with barrier elements and review recent experimental studies that provide strong support for loop extrusion, focusing on perturbations to CTCF and cohesin assayed via Hi-C in interphase. Finally, we discuss a likely molecular mechanism of loop extrusion by structural maintenance of chromosomes complexes. Keywords: genetics; biochemistry; molecular biology.
MIT Department
Massachusetts Institute of Technology. Computational and Systems Biology Program
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1101/sqb.2017.82.034710
