Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents
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nihms728608.pdf
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Accepted version
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Author(s)
Minami, Yoshiyasu
Wang, Zhao
Aguirre, Aaron D
Lee, Stephen
Uemura, Shiro
Soeda, Tsunenari
Vergallo, Rocco
Raffel, Owen C
Barlis, Peter
Itoh, Tomonori
Date Issued
2016
Journal
Coronary Artery Disease
Publisher
Ovid Technologies (Wolters Kluwer Health)
Citation
Minami, Y., et al. "Quantitative Analysis of the Side-Branch Orifice after Bifurcation Stenting Using En-Face Processing of Oct Images: A Comparison between Xience V and Resolute Integrity Stents." Coron Artery Dis 27 1 (2016): 19-28.
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Author's final manuscript
Abstract
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Objective Methods for intravascular assessment of the side-branch (SB) orifice after stenting are not readily available. The aim of this study was to assess the utility of an en-face projection processing for optical coherence tomography (OCT) images for SB evaluation. Methods Measurements of the SB orifice obtained using en-face OCT images were validated using a phantom model. Linear regression modeling was applied to estimated area measurements made on the en-face images. The SB orifice was then analyzed in 88 patients with bifurcation lesions treated with either Xience V (everolimus-eluting stent) or Resolute Integrity [zotarolimus-eluting stent (ZES)]. The SB orifice area (A) and the area obstructed by struts (B) were calculated, and the %open area was evaluated as (A-B)/A∗100. Results Linear regression modeling demonstrated that the observed departures of the intercept and slope were not significantly different from 0 (-0.12± 0.22, P=0.59) and 1 (1.01± 0.06, R2=0.88, P=0.87), respectively. In cases without SB dilatation, the %open area was significantly larger in the everolimus-eluting stent group (n=25) than in the ZES group [n=32; 89.2% (83.7-91.3) vs. 84.3% (78.9-87.8), P=0.04]. A significant difference in %open area between cases with and those without SB dilatation was demonstrated in the ZES group [91.4% (86.1-94.0) vs. 84.3% (78.9-87.8), P=0.04]. Conclusion The accuracy of SB orifice measurement on an en-face OCT image was validated using a phantom model. This novel approach enables quantitative evaluation of the differences in SB orifice area free from struts among different stent types and different treatment strategies in vivo.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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DOI of Published Version
https://doi.org/10.1097/MCA.0000000000000319
