Computational studies on the factors influencing stabilities of collagen-like peptides
Name
59133389-MIT.pdf
Description
Full printable version
Size
1.01 MB
Format
Adobe PDF
Checksum (MD5)
33781646f7f8bc510e1081a26963fa8e
Author(s)
Chang, Nai-yuan, 1973-
Advisor(s)
Bernhardt L. Trout.
Date Issued
2004
Publisher
Massachusetts Institute of Technology
Abstract
In this study, thermodynamic integration and molecular dynamics methods were used to elucidate the factors affecting stabilities of collagen-like peptides. We proposed to investigate three specific aspects: (1) the stabilizing effect of hydroxyproline (Hyp), (2) the destabilizing effect of replacing Gly, and (3) the role of water mediated hydrogen bonds. A better understanding of the origins of the stabilities of collagens will help in the design of new biomaterials and the treatment of collagen-related diseases.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.
Includes bibliographical references (leaf 26).
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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